This study explores the factors contributing to work-related burnout (WBO) among Human Resource (HR) managers in ISO-certified manufacturing firms in Malaysia. HR managers are critical as strategic business partners, driving organisational effectiveness, efficiency, and sustainability. However, the physical, mental, and emotional exhaustion they experience due to these demands is often overlooked, with limited research on WBO in this group. To address this gap, the study surveyed 311 HR managers using an online questionnaire and analysed the data using structural equation modelling with partial least squares estimation. The findings reveal that higher emotional intelligence (EQ), spiritual intelligence (SQ), and emotional labour deep-acting (ELDA) significantly reduce WBO. In contrast, emotional labour surface-acting (ELSA), which involves faking emotions, contributes to increased WBO. These results emphasise the importance of EQ and SQ in helping HR managers navigate emotional challenges and reduce burnout. Additionally, adopting ELDA strategies, where managers authentically align their emotions with the demands of their roles, is beneficial in mitigating WBO, while surface-acting worsens it. The study’s implications are critical for organizations aiming to improve HR management and overall performance. By enhancing EQ and SQ and encouraging ELDA, firms can better support HR managers’ well-being, reduce burnout, and improve productivity. This research also expands the understanding of WBO in a non-Western context, offering valuable insights for organizations in Eastern settings. Ultimately, the study provides practical recommendations for managing HR professionals’ emotional health, helping businesses foster a sustainable and productive workforce.