This study explores SANAA’s architectural approach to contemporary museum design, focusing on their innovative spatial strategies, materiality, and relationship between built forms and their surroundings. Through a comparative analysis of four key museum projects—the 21st Century Museum of Contemporary Art, the Glass Pavilion at the Toledo Museum of Art, the New Museum of Contemporary Art, and the Louvre-Lens Museum—this research examines how SANAA challenges conventional museum typologies by prioritizing openness, fluidity, and transparency. A key finding of this study is SANAA’s emphasis on dissolving rigid spatial hierarchies, allowing visitors to navigate museums freely rather than following predetermined circulation paths. The extensive use of glass, reflective aluminum, and light materials creates a dynamic interaction between interior and exterior spaces, enhancing the perception of openness. Furthermore, SANAA’s projects integrate with their urban and natural contexts, redefining the role of museums as cultural landscapes rather than isolated exhibition venues. This research highlights the architectural significance of SANAA’s approach, demonstrating how contemporary museums are evolving into dynamic, interactive environments. By analyzing spatial organization, material innovations, and contextual integration, this study contributes to a broader understanding of modern museum architecture. The findings suggest that future museums should continue embracing flexibility, openness, and user-centric spatial experiences to adapt to cultural and technological shifts. SANAA’s designs serve as a model for reimagining museum spaces, offering a paradigm that fosters engagement, movement, and interaction between people, art, and architecture.