This paper explores the evolving impact of the digital media paradigm on spatial perception and design, focusing on how virtuality, nonlinearity, and interactivity redefine architectural and artistic spaces. Through case studies including deCOi’s Hypo-Surface, James Leng’s Point Cloud, and Philip Beesley’s Epiphyte Chamber, this research reveals how these foundational digital media concepts introduce dynamic, adaptable, and modular characteristics to spatial environments. Virtuality enables variability within spaces, as modular structures allow physical forms to change fluidly while retaining functionality. Interactivity emphasizes a sensory dimension in which spaces respond actively to human presence, creating an immersive experience where users are integral to the environment’s expression. Nonlinearity introduces a cognitive and organic flow that mirrors human thought processes, promoting interconnected spaces that evolve responsively. The findings suggest a shift from static spatial design to a model where spaces are living, adaptive entities that blend human and machine characteristics. As spaces increasingly adopt organic, human-like traits, the relationship between users and architecture becomes more reciprocal, mirroring both human behaviors and mechanical responses. This new framework for spatial design provides a foundation for future explorations in digital media art and architecture, emphasizing human-centered adaptability and sensory engagement. Ultimately, this study positions digital media as a transformative force that redefines spatial expression, creating hybrid environments that encourage a continuous, interactive relationship between space and its occupants.