Virtual Reality had become popular and important in the digital society. The VR technology provides interactive experiences to raise engagement and increase knowledge retention to many subjects, including medical study. This research presented the Virtual Reality (VR) anatomical case study for learning and teaching respiratory and digestive systems. The anatomical system was developed by using three-dimensional (3D) and game-engine software. The system was operated on a high-performance personal computer and presented to the participants through fully immersive VR gears: head- mounted display and sensory handheld remote controls. The effectiveness of the program system and usage satisfaction were examined by medical and VR experts, and thirty participants. The quality of system was evaluated by the experts and was rated at a very good level (xÌ… = 4.57). The operating system and satisfaction were highly rated (xÌ… = 4.51). The results indicated that the system developed in this study was practical and applicable to educational training and future research.