In the advanced dental curriculum, students must transcend basic biochemical facts to develop diagnostic reasoning skills. This paper proposes the "Metabolic-Pathological Integration" (MPI) framework, a new pedagogical framework designed for teaching biochemistry at the postgraduate level. The framework provides a structured approach for lecturers to help students link systemic biochemical disturbances with specific oral manifestations. The MPI framework moves beyond simple analogies to focus on diagnostic logic loops, where students are taught to trace a clinical sign (e.g., periodontal destruction) back to its molecular root (e.g., oxidative stress and collagen degradation). This framework offers biochemistry lecturers a roadmap for transforming abstract metabolic data into actionable clinical intelligence, thereby fostering high-order critical thinking in postgraduate dental education.