Although many improvements in the prevention of fatalities in construction industry, however, the fatality rates in Malaysian Construction Industry continue at an unacceptable rate. Data extracted from Department of Occupational Safety & Health (DOSH) Malaysia, indicated that Safety Measure Practices (SMP) were the main cause of workers’ high fatality. The purpose of this study is to investigate the relationship of SMP, Safety Performance, and Project Performance at Occupational Health & Safety Management System (OHSMS) certified Malaysia construction projects. This study was conducted using purpose sampling, a self-administrated questionnaire at 31 project sites consisting of 401 respondents within the safety management team members in the state of Selangor, Malaysia. The data analysis in this study was carried out using SPSS Amos (v21) of IBM. The findings show that Safety Rules & Procedures, Safety Acts and Adoption of OHSMS of SMP are positively related to safety performance and project performance. Furthermore, these elements of safety components shall upgrade company image and improve financial gains of the project. Within the scope of the unique nature of the project, implementing SMP in OHSMS environment, with special reference to Safety Rules & Procedures and Safety Acts of the workers results in less workplace accidents. Also, project performance (company competitiveness and financial performance) will be enhanced through better safety performance. The key findings may prompt the top management and project managers to re-think the current conservative approach to run the projects where safety issues are fully responsible by the safety team. Top management need to top-up resources to manage safety as like other functions of the business.  Project managers need to manage safety besides the other functions of the organization such as production, maintenance, marketing and finance to achieve business objectives.