Stroke is one of the leading causes of death and disability globally. According to the findings, there are 16 million strokes annually, with 6 million deaths and another 5.5 million left with significant disability with enormous health, social and economic impact worldwide. Depressions and symptoms associated with it can be severe and may lead to life-threatening issues, hence this study is undertaken with an aim to highlight its importance and how detrimental it can be when it has adverse effects on the lives of many. When it comes to the possible solutions, and in the current tech era innovation can play an imperative role in addressing post-stroke depression (PSD) by offering novel methods of prevention, diagnosis, treatment, and management. This study focused on depression and post-symptoms, and those issues can be mitigated to some extent while embracing innovation and leveraging available technologies. This study mainly focuses on how healthcare providers can enhance the prevention, detection, and treatment of post-stroke depression, ultimately improving the well-being and quality of life of stroke survivors by using different innovative sets of methods and reducing the cost of any health system. This study took the viewpoint of 50 individuals (both male and female) and analysis further confirmed the use of innovation was quite helpful, even when the majority of affected individuals were not able to see and reach the health professional in person, then innovation led measures helped to optimize depression self-management, accelerate social support, and strengthen connections between stroke survivors and health care provider. When we are moving towards innovation and new technologies are acting as the cornerstones in the health system, hence then such findings will help the system to facilitate the affected population in a far better and more promising way. From the SDGs perspective, enhanced scientific research and, use of the technological and existing capabilities in the health sector, especially pertaining to post-stress depression, with a prime focus on the encouraged innovation and sustainability will allow for the overall contribution and attainment of 2030 sustainable development goals.