Kajian berkaitan dengan pemupukan kemahiran abad ke-21 dalam bioteknologi Tingkatan 6 di Malaysia jarang dilaksanakan. Kajian rintis ini bertujuan untuk mengkaji persepsi pelajar tentang penggunaan modul bioteknologi, M-Biotek-STEM (MBS) dalam pemupukan kemahiran literasi era digital dan kemahiran literasi inventif. Tinjauan telah dijalankan ke atas 12 pelajar berusia 17-18 tahun Kolej Tingkatan 6 di daerah Kinta Utara, Perak dengan instrumen borang soal selidik T6-KA21. Dapatan kajian dianalisis dengan ujian ANOVA satu hala. Dapatan kajian menunjukkan bahawa tiada kesan yang utama faktor jantina dan Gred Sains Peperiksaan Menengah Rendah (PMR) terhadap pemupukan kemahiran abad ke-21 dalam pembelajaran topik bioteknologi. Dapatan juga menunjukkan bahawa pelajar secara puratanya berpendapat bahawa modul MBS boleh memupuk kemahiran literasi era digital dan kemahiran literasi inventif dalam masa pendedahan yang lebih lama.

Abstract: Research related to inculcation of 21^st century skills in sixth form (equivalent to GCE A-level) biotechnology were seldom conducted in Malaysia. This pilot study was carried out to investigate the perception of students using the biotechnology module, M-Biotek-STEM (MBS) to foster the 21^st century skills, digital era literacy skills and inventive skills. A survey was conducted with 12 students, aged 17-18 years old, from a Form 6 College (Kolej Tingkatan 6) in Kinta Utara district, Perak. The instrument used was T6-KA21 questionnaire. The results were analysed with one-way ANOVA. Results showed that there were no significant effect between sex and lower secondary examination (PMR) Science score towards the inculcation of 21^st century skills in biotechnology topic. Results also showed that the students averagely agreed that the MBS module was able to foster digital era literacy skills and the inventive skills in longer period of time.