It is well known that social media applications in education play significant roles in teaching reformation and learning style transformation. The popular social media Tik Tok with its unique functions and special characteristics has successfully attracted broad attention from younger millennials. With the rapid development tendency of Tik Tok application in education, it is very important and urgent to review the effect of Tik Tok application in student learning. However, the current literature mainly focused more on the review on online learning and social media such as Facebook, Blogs, and Twitter. Though there existed literature review on Tik Tok, Tik Tok was only mentioned and just treated as part of social media. To date, no study has reviewed student learning with Tik Tok, particularly concerning learning outcomes, student psychology, learning challenges, and improvement strategies. This article bridges the gap through content analysis on relevant literature. The main conclusion is that Tik Tok has a positive effect on students’ learning outcome and negative effect on student psychology. Main challenges include unhealthy information and entertainment orientation content, frequent psychological problems among college students and new social media platform application, and traditional knowledge-oriented teaching. Curriculum development is highlighted as the principal avenue for advancing student learning via TikTok integration.