Mobile health (mHealth) applications are increasingly recognized as a promising solution for health monitoring and management, offering patients a convenient and secure way to track their health, particularly in the management of common and chronic diseases. Despite these benefits, widespread adoption remains a challenge due to various factors affecting user acceptance. This conceptual paper explores the mediating role of trust to key factors influencing Malaysian users' behavioural intentions to adopt mHealth applications. Specifically, the paper explores the impact of privacy concerns, perceived risks, trust in health data, and trust in mHealth systems on users' willingness to adopt these technologies. A quantitative cross-sectional survey design will be employed to collect data from the public in Malaysia, aiming to provide insights into users' perceptions and attitudes towards mHealth applications. The findings will be expecting to shed light on both the benefits of mHealth applications and the concerns that may hinder their adoption. This conceptual paper will argue the mediate role of trust in increasing of the usages of mHealth applications presents significant to improve the health condition. Building user trust in mHealth technologies and effectively addressing concerns related to data privacy and system trustworthiness. Additionally, the integration of clinical and health data through mHealth applications can lead to improved efficiency and effectiveness in managing patients' health, offering a more seamless and proactive approach to healthcare. This conceptual paper contributes to the existing body of knowledge by conceptualise the antecedents of users’ behavioural intentions toward mHealth applications, offering new insights into the factors that influence their decision to adopt such technologies. This conceptual paper provides valuable guidance for both healthcare practitioners and technology developers in shaping the future of digital health. The findings are expected to have implications for policy makers, healthcare institutions, and app developers, helping them to foster greater user engagement and to expand the adoption of mHealth technologies in Malaysia's evolving healthcare landscape.