Background: The Dunhuang murals, as a treasure of ancient Silk Road civilization, are seriously threatened by environmental degradation and human factors, and such endangered documents should receive innovative digital preservation strategies. The richness of these artworks’ historical, religious, and cultural narratives is encapsulated in these artworks for which they remain so fragile, presenting interdisciplinary solutions to them is necessary to guarantee their survival and accessibility. Aims: The purpose of this study is to examine how the methodologies of interdisciplinary research (art history, computer science, communication theory) can be employed to digitize Dunhuang murals, to assess the strategies of data collection and analysis and to offer systematic guidelines of digital preservation and global dissemination of the data. Methods: A mixed-methods approach combines qualitative interviews with experts, technologists, and audiences, alongside quantitative surveys and technical data analysis (high-resolution scans, 3D models, and social media analytics). Synthetic conclusions both from the human side (through thematic analysis, and the technical side (with statistical tools such as SPSS and Python) are undertaken on a rigorous basis. Here the study underscores the adherence to RECUKM guidelines such as the ethical compliance to participant rights and data integrity.