Health Communication was defined in the 90’s as any types of communication that affect the well-being of any individual through healthcare delivery and health promotion. The definition further elaborated as all health information and missive transmitted to the public at large for creating health awareness, healthy skills and impact positive attitude to healthy lifestyle and quality of life. Effective health communication will shift social norms, ensuring social determinants health, optimal health outcomes and well-being on global scale. Health Literacy is later introduced as any biomedical evidence and mediator of health impacts involving health equity, healthcare efficiency and health motivation endorse on wellbeing and quality of life. Digital Health Literacy or e-health further defines as all dominance of mechanical and technology applications, platforms and system to create a transformation pathway of new knowledge and insights on healthcare settings and delivery to achieve health equity and mitigate health disparities (Taboada-Villamarin et al. 2024). The objective of this study is to depict and dwell into the importance of food and nutritional information in Health Literacy and the influence of health motivation on sociodemographic, socioeconomic, cultural and environmental within the whole healthcare ecosystem. Food and nutritional information are vital elements for holistic and wellbeing route to population across the globe. Dietary preference and nutritional perception align and comprehend fundamental public health policy. Health literacy levels determine effective health outcomes and health related decisions pressure by motivation such as economic, cultural, emotional and environment. The Qualitative methodology will be adopted to provide observation and overview of the challenges and impression on the importance of food and nutritional information in health literacy multidisciplinary aspects and framework of the healthcare panoramic structure. Food and nutritional literacy play a crucial role in the whole health ecosystem landscape. The findings here suggested that health literacy remains a universal challenge due to sociodemographic, socioeconomic, cultural and environmental differences on attitudes and understanding of nutritional values and food choices. In conclusion, this case study will unveil the significance on food and nutritional literacy in health communication and literacy especially during the panic moment of a pandemic outbreak like Covid-19 in 2020 and devastated situation to resolve health and disease management. Deficiency in health literacy will create challenges in wellbeing which contribute impact to global poverty, inequality and disparities in the healthcare system.